Genome-wide analysis of differentially expressed lncRNA in sporadic parathyroid tumors.

Affiliation

Department of Otorhinolaryngology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China. [Email]

Abstract

Diagnosis of parathyroid carcinoma on histological examination is challenging. Thousands of differentially expressed lncRNAs were identified on the microarray data between parathyroid cancer and adenoma samples. Four lncRNAs were significantly dysregulated in further validation. The "lncRNA score" calculated from these lncRNAs differentiated parathyroid carcinomas from adenomas. LncRNAs serve as biomarkers for parathyroid cancer diagnosis.

Keywords

diagnosis,hyperparathyroidism,lncRNAs,parathyroid tumors,