Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.

Affiliation

Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Erwin Mill Building, 2024 W. Main St., Durham, NC, 27705, USA. [Email]

Abstract

Alzheimer's disease (AD) is the most common cause of dementia in the elderly and the sixth leading cause of death in the United States. AD is mainly considered a complex disorder with polygenic inheritance. Despite discovering many susceptibility loci, a major proportion of AD genetic variance remains to be explained.

Keywords

Alzheimer’s disease,Gene-based analysis,Genome-wide association study,Meta-analysis,Sex disparities,