Grading Noninvasive Bladder Cancer: World Health Organisation 1973 or 2004 May Be the Wrong Question.


Department of Cellular Pathology, University Hospital of Wales, Cardiff, UK. Electronic address: [Email]


The clinical utility of the World Health Organisation 1973 and 2004 systems for grading bladder cancer are limited by inclusion of biologically heterogeneous categories of grade 2 and high grade, respectively. Reporting both systems in parallel would improve risk stratification by splitting these categories.