Gum Tragacanth (GT): A Versatile Biocompatible Material beyond Borders.


Taghavizadeh Yazdi ME(1), Nazarnezhad S(2), Mousavi SH(1), Sadegh Amiri M(3), Darroudi M(4), Baino F(5), Kargozar S(2).
Author information:
(1)Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran.
(2)Tissue Engineering Research Group
(TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran.
(3)Department of Biology, Payame Noor University, Tehran 43183-1455, Iran.
(4)Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran.
(5)Applied Science and Technology Department, Institute of Materials Physics and Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.


The use of naturally occurring materials in biomedicine has been increasingly attracting the researchers' interest and, in this regard, gum tragacanth (GT) is recently showing great promise as a therapeutic substance in tissue engineering and regenerative medicine. As a polysaccharide, GT can be easily extracted from the stems and branches of various species of Astragalus. This anionic polymer is known to be a biodegradable, non-allergenic, non-toxic, and non-carcinogenic material. The stability against microbial, heat and acid degradation has made GT an attractive material not only in industrial settings (e.g., food packaging) but also in biomedical approaches (e.g., drug delivery). Over time, GT has been shown to be a useful reagent in the formation and stabilization of metal nanoparticles in the context of green chemistry. With the advent of tissue engineering, GT has also been utilized for the fabrication of three-dimensional (3D) scaffolds applied for both hard and soft tissue healing strategies. However, more research is needed for defining GT applicability in the future of biomedical engineering. On this object, the present review aims to provide a state-of-the-art overview of GT in biomedicine and tries to open new horizons in the field based on its inherent characteristics.