High GD2 expression defines breast cancer cells with enhanced invasiveness.


Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Nuclear Oncology, Memorial Sloan Kettering Cancer Center, New York, USA. Electronic address: [Email]


Breast cancer is the most frequently diagnosed cancer among women. Cancer stem cells (CSCs) are suggested to be responsible for tumor initiation, progression, metastasis, recurrence and drug resistance. This study was conducted to evaluate the clinical significance of GD2, a newly suggested CSC marker and two other traditional CSC markers, CD44 and CD24 in breast cancer patients.


Breast cancer,CD24,CD44,Cancer stem cells,GD2,Tissue microarray,