Human cystatin SN is an endogenous protease inhibitor that prevents allergic rhinitis.


Department of Immunology, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address: [Email]


Protease allergens disrupt epithelial barriers to exert their allergenicity. Cystatin SN (encoded by CST1) is an endogenous cysteine protease inhibitor upregulated in nasal epithelia in patients with allergic rhinitis (AR).


Allergic rhinitis,cystatin SN,nasal epithelial cells,protease,tight junctions,