Hutchinson-Gilford Progeria Syndrome: Cardiovascular Pathologies and Potential Therapies.

Affiliation

Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. Electronic address: [Email]

Abstract

Hutchinson-Gilford progeria syndrome (HGPS) is an ultrarare and fatal disease with features of premature aging and cardiovascular diseases (atherosclerosis, myocardial infarction, and stroke). Several landmark studies in 2018-2019 have revealed novel mechanisms underlying cardiovascular pathologies in HGPS, and implicate future potential therapies for HGPS, and possibly physiological aging.

Keywords

Hutchinson–Gilford progeria syndrome,atherosclerosis,nuclear lamins,pharmacotherapy,physiological aging,progeria,