Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature.

Affiliation

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY; Laboratory for Investigative Dermatology, Rockefeller University, New York, NY. Electronic address: [Email]

Abstract

Ichthyoses are a group of rare skin disorders lacking effective treatments. Although genetic mutations are progressively delineated, comprehensive molecular phenotyping of ichthyotic skin could suggest much-needed pathogenesis-based therapy.

Keywords

IL-17,IL-36,Netherton syndrome,Psoriasis,TNF-α,atopic dermatitis,congenital ichthyosiform erythroderma,epidermal barrier,epidermolytic ichthyosis,immune,inflammation,lamellar ichthyosis,precision medicine,targeted therapy,

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