Immunoglobulin E-Mediated Food Allergies Differ in East Mediterranean Children Aged 0-2 Years.


Department of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Turkey, [Email]


OBJECTIVE : Precise diagnosis of allergy requires knowledge of the population's food allergy (FA) spectrum and predictors.
METHODS : Medical charts of Turkish children aged 0-2 years with FA and/or atopic dermatitis (AD) were reviewed.
RESULTS : A total of 1,389 patients, 912 with FA and 1,140 with AD, were included. In the FA group, the most frequently diagnosed FAs were egg white (75.9%), cow's milk (55.7%), tree nuts (31.5%) and sesame (20.6%). The detection of FA in 99% of children with any kind of FA necessitate testing with egg white, cow's milk, hazelnut, sesame, walnut, cashew, and pistachio. In the FA group, 72.7 and 56.8% had AD and multiple FA respectively. Multiple FA (56.8 vs. 49.8%) and hen's egg allergy (85.5 vs. 50.2%, p < 0.005) were more common and cow's milk allergy (51.4 vs. 67.1%, p < 0.005) less common in the AD subgroup of the FA group than in the non-AD subgroup. Multiple FA likelihood increases parallel to the severity of AD (p < 0.05). In the AD group, 58.2% had an immunoglobulin E-mediated FA. The risk of concomitant FA increased as the age at symptom onset of AD decreased (OR 0.800 [95% CI 0.731-0.875]; p < 0.001) and the severity of AD increased (OR 2.350 [95% CI 1.898-2.911]; p < 0.001).
CONCLUSIONS : Although severe and early-onset AD is a predictor of the presence and magnitude of FA in infancy, the spectrum of FA is a reflection of cultural characteristics. The clinical presentations of both AD and FA may in fact be an expression of the extent of the immune dysregulation underlying atopy and allergy.


Atopic dermatitis,Breast feeding,Food allergy,Infant,Skin prick test panel,

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