Impact of gene polymorphisms on the systemic toxicity to paclitaxel/carboplatin chemotherapy for treatment of gynecologic cancers.


Coordenação de Pesquisa, Instituto Nacional do Câncer, Rio de Janeiro, RJ, Brazil. [Email]


Gynecologic malignancies are often detected in advanced stages, requiring chemotherapy with taxane/platinum combinations, which may cause severe toxicities, such as neutropenia and peripheral neuropathy. Gene polymorphisms are suspected as possible causes for the interindividual variability on chemotherapy toxicities.


ABCB1,CYP2C8*3,Gene polymorphisms,Ovarian cancer,Paclitaxel toxicity,Uterine cancers,