In vivo assessment of the mechanical properties of crystalline lenses in a rabbit model using ultrasound elastography: Effects of ultrasound frequency and age.


School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China; National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen, China; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, China; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States. Electronic address: [Email]


The occurrence of presbyopia and cataract is closely related to changes in the mechanical properties of the crystalline lens. There are no established methods so far for in vivo assessment. By introducing ultrasound elastography, we proposed group velocity (Vg) of an induced shear wave as a new biomarker to characterize the mechanical properties of the lens in our previous study. Here, we investigated the effect of the ultrasound frequency on measurement accuracy and validated the results with a conventional ex vivo compression testing. We also demonstrated a change trend in Vg and its correlation with age in a rabbit model.


Acoustic radiation force,Age,Crystalline lens,Frequency,Mechanical properties,Shear wave,Ultrasound elastography,