In vivo evaluation of thiol-functionalized superparamagnetic iron oxide nanoparticles.


Department of Chemistry, Federal University of São Paulo, Diadema, SP, Brazil. Electronic address: [Email]


This article describes the synthesis, characterization and in vivo cytotoxic evaluation of thiol-functionalized superparamagnetic iron oxide magnetic nanoparticles (SPIONs). They have been employed as potential vehicles for a large number of biomedical applications, such as drug delivery. Fe3O4 nanoparticles were synthesized by coprecipitation of iron salts and coated with L-cysteine. The physicochemical, morphological, and magnetic properties of Cys-Fe3O4 nanoparticles were characterized by different experimental techniques. To evaluate their applicability in nanomedicine we evaluated their cytotoxicity using Balb/C mice. The results show that Cys-SPIONs are good candidates as nanocarriers in biomedical applications.


Biocompatibility,Cytotoxicity,Drug delivery,Iron oxide,Nanoparticles,

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