Induction of airway remodeling and persistent cough by repeated citric acid exposure in a guinea pig cough model.

Affiliation

Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan. Electronic address: [Email]

Abstract

A previous study involving guinea pigs showed that repeated cough could increase peripheral airway smooth muscle area, which can also aggravate cough. The airway pathologic changes produced by prolonged cough are still unknown.

Keywords

Airway remodeling,Cough,Cough reflex sensitivity,Mechanical stress,

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