Influence of early adversity on cortisol reactivity, SLC6A4 methylation and externalizing behavior in children of alcoholics.

Affiliation

Molecular Genetics Lab, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India. Electronic address: [Email]

Abstract

Children of parents with alcoholism face considerable stress, and often have externalizing behaviors. Early adversity is known to affect DNA methylation and the functioning of the HPA axis. We investigated the association of early adversity with cortisol reactivity, 5HTTLPR genotype, site specific DNA methylation in the SLC6A4 gene and externalizing behavior in children of alcoholics (COA), and a matched sample of control children.

Keywords

Children of alcoholics,Cortisol reactivity,DNA methylation,Early adversity,Externalizing behavior,SLC6A4,