Inhibiting casein kinase 2 overcomes paclitaxel resistance in gastric cancer.

Affiliation

Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, 51 Yonsei-Ro, Seodaemun-gu, Seoul, 120-752, Korea. [Email]

Abstract

Casein kinase (CK) 2 activation has been implicated in the proliferation of various tumor types and resistance to chemotherapy. We investigated the mechanistic basis for the association between CK2 activation and paclitaxel resistance in a gastric cancer (GC).

Keywords

Casein kinase 2,Drug resistance,Gastric cancer,Paclitaxel,

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