Interplay between host-microbe and microbe-microbe interactions in cystic fibrosis.

Affiliation

Microbiology and Molecular Genetics, University of Pittsburgh, United States. Electronic address: [Email]

Abstract

The respiratory tract of individuals with cystic fibrosis is host to polymicrobial infections that persist for decades and lead to significant morbidity and mortality. Improving our understanding of CF respiratory infections requires coordinated efforts from researchers in the fields of microbial physiology, genomics, and ecology, as well as epithelial biology and immunology. Here, we have highlighted examples from recent CF microbial pathogenesis literature of how the host nutritional environment, immune response, and microbe-microbe interactions can feedback onto each other, leading to diverse effects on lung disease pathogenesis in CF.

Keywords

Antimicrobial resistance,Biofilm,Infection,Lung,Pathogenesis,Polymicrobial,

OUR Recent Articles