Keys to unlock androgen receptor translocation.


From Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, British Columbia V5Z 1L3, Canada [Email]


The androgen receptor (AR) is tightly linked to prostate cancer, but the mechanisms by which AR transactivation is dysregulated during cancer progression are not fully explored. Dagar et al. examined AR translocation to the nucleus to identify a link between heat shock protein 90 (HSP90) and protein kinase A (PKA). Their findings provide a potential mechanism of the initiation of AR transactivation and potential targets for developing and refining treatments for prostate cancer.