Knockout of Canopy 2 activates p16INK4a pathway to impair cardiac repair.


Toronto General Hospital Research Institute, Division of Cardiovascular Surgery, University Health Network, Toronto, ON, Canada; Division of Cardiac Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada. Electronic address: [Email]


Cardiac repair depends on angiogenesis and cell proliferation. Previously we identified Canopy 2 (CNPY2) as a secreted angiogenic growth factor which promotes neovascularization. We investigated the role of CNPY2 in cardiac repair following myocardial infarction (MI) and the possible mediators involved using Cnpy2 knockout (KO) mice and human cardiac tissue.


Canopy 2,Cardiac repair,Heart failure,Myocardial infarction,p16(INK4a),