Large-scale production and directed induction of functional dendritic cells ex vivo from serum-free expanded human hematopoietic stem cells.

Affiliation

Department of Chemical Engineering and Materials Science, Yuan Ze University, Chung-Li District, Taoyuan City, Taiwan. Electronic address: [Email]

Abstract

Dendritic cells (DCs) that are derived from hematopoietic stem cells (HSCs) are the most potent antigen-presenting cells and play a pivotal role in initiating the immune response. Hence, large-scale production and direct induction of functional DCs ex vivo from HSCs are crucial to HSC research and clinical potential, such as vaccines for cancer and immune therapy.

Keywords

dendritic cells,ex vivo expansion,hematopoietic stem cells,immunotherapy,induction,