Laser-Synthesized SERS Substrates as Sensors toward Therapeutic Drug Monitoring.


Laboratorio di Patologia Clinica e Genetica Medica, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, Italy. [Email]


The synthesis by pulsed laser ablation and the characterization of both the surface nanostructure and the optical properties of noble metal nanoparticle-based substrates used in Surface Enhanced Raman Spectroscopy are discussed with reference to application in the detection of anti-epileptic drugs. Results on two representative drugs, namely Carbamazepine and Perampanel, are critically addressed.


antiepileptic drugs,noble metal nanoparticles,pulsed laser ablation,surface enhanced Raman spectroscopy,

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