Lean mass, grip strength and risk of type 2 diabetes: a bi-directional Mendelian randomisation study.


School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 7 Sassoon Road, Pokfulam, Hong Kong SAR, China. [Email]


Muscle mass and strength may protect against type 2 diabetes as a sink for glucose disposal. In randomised controlled trials, resistance training improves glucose metabolism in people with the metabolic syndrome. Whether increasing muscle mass and strength protects against diabetes in the general population is unknown. We assessed the effect of markers of muscle mass and strength on diabetes and glycaemic traits using bi-directional Mendelian randomisation.


Body composition,Diabetes mellitus,Grip strength,Hand strength,Lean mass,Mendelian randomisation,Muscle,Type 2 diabetes,

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