Let-7 inhibits the migration and invasion of extravillous trophoblast cell via targeting MDM4.

Affiliation

Department of OCbstetrics, Gansu Maternal and Child Health Care Hospital, China. Electronic address: [Email]

Abstract

Extravillous trophoblast (EVT) cells migration and invasion are important causes to preeclampsia (PE). Studies have shown that let-7 was involved in inhibiting proliferation and invasion of several cancer cells, however, its effect on EVT cells migration and invasion has hardly been reported. This study aimed to explore the relation between let-7 and EVT cell migration and invasion.

Keywords

Extravillous trophoblast,Invasion,Let-7,Migration,Murine double minute 4,

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