Levodopa imparts a normalizing effect on default-mode network connectivity in non-demented Parkinson's disease.


Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: [Email]


Parkinson's disease (PD) is characterized with reduced dopamine level in the brain, resulting from the nigral degeneration. It is commonly accepted that the function of default mode network (DMN) is disturbed in PD, even in those who have no significant cognitive impairment. However, the relationship between the depletion of dopamine and DMN dysconnectivity is not fully clear. The aim of this study was to investigate the seed-based DMN connectivity and the influence of dopaminergic therapy on the DMN integrity in non-demented PD by using resting-state fMRI.


Default mode network,Functional connectivity,Parkinson’s disease,Resting-state functional MRI,

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