Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms.


Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont. Electronic address: [Email]


Studying the neural consequences of tobacco smoking during adolescence, including those associated with early light use, may help expose the mechanisms that underlie the transition from initial use to nicotine dependence in adulthood. However, only a few studies in adolescents exist, and they include small samples. In addition, the neural mechanism, if one exists, that links nicotinic receptor genes to smoking behavior in adolescents is still unknown.


Adolescents,Genetics,Gray matter volume,Low smoking exposure,Neuroimaging,fMRI,