Low entropy of interictal gamma oscillations is a biomarker of the seizure onset zone in focal cortical dysplasia type II.


Department of Neurosurgery, Showa University School of Medicine, Tokyo, Japan; Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: [Email]


Dynamic changes in the regularity of interictal gamma oscillations (GOs, 30-70 Hz) on intracranial electroencephalography (EEG) reflect focal ictogenesis with epileptogenic neuronal synchronization in focal cortical dysplasia (FCD). We investigated whether the regularity of interictal GOs is a biomarker of the seizure onset zone (SOZ) using multiscale entropy analysis.


Epileptogenic lesion,Focal cortical dysplasia,Gamma oscillations,Multiscale entropy,Seizure onset zone,