Maternal rotating night shift work before pregnancy and offspring stress markers.


Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States of America; Department of Epidemiology, Center for Public Health, Medical University of Vienna, Austria; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States of America. Electronic address: [Email]


Recent studies suggest an intergenerational influence of stress such that maternal exposure even before pregnancy could impact offspring health outcomes later in life. In humans, investigations on the impact of maternal stressors on offspring health outcomes, including stress-sensitive biomarkers, have largely been limited to extreme stressors. Prior studies have not addressed more moderate maternal stressors, such as rotating night shift work, on offspring stress markers in young adulthood.


Circadian disruption,Cortisol,Intergenerational,Maternal night shift work,Offspring stress,Salivary alpha amylase,