Melatonin attenuates white matter damage after focal brain ischemia in rats by regulating the TLR4/NF-κB pathway.

Affiliation

Department of Ophthalmology, Affiliated Hospital, Weifang Medical University, Weifang, Shandong 261031, China. Electronic address: [Email]

Abstract

To assess the possible neuroprotective effects of melatonin against brain white matter damage via the Toll-like receptor 4 (TLR4)/ nuclear factor-kappa B (NF-κB) signaling pathway in focal cerebral ischemic rats.

Keywords

Brain ischemia,Diffusion tensor imaging,Melatonin,TLR4/NF-κB signaling,White matter,

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