Metal-free synthesis of activated ynesulfonamides and tertiary enesulfonamides.


Equipe Synthèse Organique et Phytochimie, Institut de Chimie, CNRS-UdS UMR 7177, 4, rue Blaise Pascal CS 90032, 67081 Strasbourg, France. [Email]


An operationally simple synthesis of activated ynesulfonamides and enesulfonamides is described. Ynesulfonamides can be obtained through reaction of sulfonylamides with activated bromoalkynes and Triton B in a short time at room temperature. Likewise, terminal alkynes react with sulfonylamides to provide enesulfonamides. Z/E enesulfonamides can be transformed exclusively into E enesulfonamides.

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