Methods to edit T cells for cancer immunotherapy.


INSERM U932, PSL University, Institut Curie, Paris, France. Electronic address: [Email]


This chapter summarizes the recent findings regarding the development of gene-editing technologies applied to adoptive T cell immunotherapy for cancer. The emerging tools and strategies described below enable the generation of a tailored system, establishing T cells as an advanced biomaterial with redirected specificities that are both programmable and inducible and establish long-term antitumor potential. These reviewed techniques and strategies are implemented with an optimized protocol for the generation of CAR-T cells using lentiviral gene transfer.


Adoptive transfer,Cancer immunotherapy,T cells engineering,

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