Model-based Voriconazole Dose Optimization in Chinese Adult Patients With Hematologic Malignancies.

Affiliation

Department of Pharmacy, Peking University Third Hospital, Beijing, China; Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address: [Email]

Abstract

The objective of this study was to characterize the population pharmacokinetics of voriconazole and to identify factors that significantly affect pharmacokinetic parameters and to further investigate optimal dosage regimens in Chinese adult patients with hematologic malignancies.

Keywords

Monte Carlo simulation,dose optimization,hematologic malignancies,population pharmacokinetics,voriconazole,

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