Molecular alterations induced by Yersinia pestis, dengue virus and Staphylococcal enterotoxin B under severe stress.


Systems Biology Enterprise, U.S. Army Center for Environmental Health Research, Fort Detrick, MD 21702, USA; Department of Bioinformatics, Advanced Academic Program, Johns Hopkins University, Baltimore, MD 21218, USA; The Geneva Foundation, Frederick, MD 21702, USA. Electronic address: [Email]


Severe stress can have drastic and systemic effects with dire implications on the health and wellbeing of exposed individuals. Particularly, the effect of stress on the immune response to infection is of interest to public health because of its implications for vaccine efficacy and treatment strategies during stressful scenarios. Severe stress has previously been shown to cause an anergic state in the immune system that persists following exposure to a potent mitogen.


Biomarkers,Dengue virus,Gene expression,Immune response,Staphylococcal enterotoxin B (SEB),Stress,US Army Ranger Training Battalion (RASP: Rangers Assessment and Selection Program),Yersinia pestis (plague),