Monitoring matrix metalloproteases based on the selective interaction between an Ir(iii) solvent complex and a histidine-rich polypeptide.

Affiliation

College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, People's Republic of China. [Email] [Email]

Abstract

A luminescent biosensor has been developed for matrix metalloproteinase 9 (MMP-9) assays based on the selective interaction between an Ir(iii) solvent complex and a histidine-rich peptide, which avoids the complicated double labeling of substrate polypeptides commonly-used in FRET MMP detections and provides a promising strategy for MMP detection in clinical applications.

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