Multiparameter MRI quantification of microstructural tissue alterations in multiple sclerosis.

Affiliation

GIGA - CRC in vivo Imaging, University of Liège, Liège, Belgium; Clinical Neuroimmunology Unit, Neurology Department, CHU Liège, Belgium. Electronic address: [Email]

Abstract

Conventional MRI is not sensitive to many pathological processes underpinning multiple sclerosis (MS) ongoing in normal appearing brain tissue (NABT). Quantitative MRI (qMRI) and a multiparameter mapping (MPM) protocol are used to simultaneously quantify magnetization transfer (MT) saturation, transverse relaxation rate R2* (1/T2*) and longitudinal relaxation rate R1 (1/T1), and assess differences in NABT microstructure between MS patients and healthy controls (HC).

Keywords

Histological MRI,Multiple sclerosis,Quantitative MRI,Relaxometry,

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