NK-cell responses are biased towards CD16-mediated effector functions in chronic hepatitis B virus infection.

Affiliation

Department of Medicine II, University Hospital Freiburg - Faculty of Medicine, University of Freiburg, Hugstetter Straße 55, Freiburg 79106, Germany. Electronic address: [Email]

Abstract

Phenotypic and functional natural killer (NK)-cell alterations are well described in chronic hepatitis B virus (cHBV) infection. However, it is largely unknown whether these alterations result from general effects on the overall NK-cell population or the emergence of distinct NK-cell subsets. Human cytomegalovirus (HCMV) is common in cHBV and is associated with the emergence of memory-like NK cells. We aimed to assess the impact of these cells on cHBV infection.

Keywords

Adaptive,CD16,Chronic hepatitis B virus infection,Human cytomegalovirus,Memory-like,NK cells,