NSAID administration post colorectal surgery increases anastomotic leak rate: systematic review/meta-analysis.


Department of General Surgery, Memorial University of Newfoundland, 300 Prince Philip Dr, St. John's, NL, A1B 3V6, Canada. [Email]


Current enhanced recovery guidelines suggest that opioid sparing medications should be used for analgesia whenever possible following colorectal surgery. The present study aims to assess whether post-operative NSAID use is associated with an increased anastomotic leak rate after a colonic or rectal anastomosis.


Anastomotic leak,Colorectal anastomosis,Early recovery after surgery (ERAS),Non-steroidal anti-inflammatory drugs (NSAIDs),