Nature of T cell epitopes in lupus antigens and HLA-DR determines autoantibody initiation and diversification.


Division of Rheumatology, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA [Email]


The generation of systemic lupus erythematosus (SLE)-related autoantibodies have been shown to be T cell dependent and antigen driven with HLA-DR restriction. In this study, the initiating antigen(s) and the mechanism of autoantibody diversification were investigated.


HLA-DR,SLE,T cell epitopes,autoantibody,molecular mimicry,