Near-infrared Fluorescence Ocular Imaging (NIRFOI) of Alzheimer's Disease.

Affiliation

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129, USA. [Email]

Abstract

Near-infrared fluorescence (NIRF) imaging has been widely used in preclinical studies; however, its low tissue penetration represents a daunting problem for translational clinical imaging of neurodegenerative diseases. The retina is known as an extension of the central nerve system (CNS), and it is widely considered as a window to the brain. Therefore, the retina can be considered as an alternative organ for investigating neurodegenerative diseases, and an eye represents an ideal NIRF imaging organ, due to its minimal opacity.

Keywords

Alzheimer’s disease,Amyloid beta,NIRF probes,Near-infrared fluorescence ocular imaging,Ocular imaging,

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