Neural mechanisms of expectancy-based placebo effects in antidepressant clinical trials.


Department of Psychology, University of Haifa Mount Carmel, Haifa, 31905, Israel. Electronic address: [Email]


Patient expectancy of therapeutic improvement is a primary mediator of placebo effects in antidepressant clinical trials, but its mechanisms are poorly understood. This study employed a novel antidepressant trial design, with integrated functional magnetic resonance imaging (fMRI), to manipulate patient outcome expectancy and examine its neural mediators.


Antidepressants,Clinical trials,Outcome expectancy,Pharmacotherapy,Placebo effect,

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