No IL-18BP? Avoid HAV.


Departments of Medicine, Molecular Microbiology, Pathology & Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO [Email]


Fulminant viral hepatitis occurs in a very small number of infected individuals. Until now, the basis for this phenotype has remained unknown. In this issue of JEM, Belkaya et al. ( identify a deletion in the IL18BP gene in a severely affected child that results in excessive natural killer cell activation and uncontrolled killing of hepatocytes.

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