No IL-18BP? Avoid HAV.

Affiliation

Departments of Medicine, Molecular Microbiology, Pathology & Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO [Email]

Abstract

Fulminant viral hepatitis occurs in a very small number of infected individuals. Until now, the basis for this phenotype has remained unknown. In this issue of JEM, Belkaya et al. (https://doi.org/10.1084/jem.20190669) identify a deletion in the IL18BP gene in a severely affected child that results in excessive natural killer cell activation and uncontrolled killing of hepatocytes.

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