No Sugar Added: A New Strategy to Inhibit Glioblastoma Receptor Tyrosine Kinases.


Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan. [Email]


A novel inhibitor of N-linked glycosylation (NGI-1) inhibits the glycosylation and phosphorylation of multiple receptor tyrosine kinases in glioblastoma (GBM). NGI-1 sensitizes multiple models of GBM to chemotherapy and radiation in vitro and in vivo and may be especially effective in GBMs that retain active PTEN.See related article by Baro et al., p. 784.