BACKGROUND : Chronic hepatitis C virus (HCV) infection, that is defined by active carriage of HCV RNA in the blood, is represents one of the major public health problems worldwide. In Serbia, the prevalence of anti-HCV positive persons in the general population, is estimated on average 1.13%. METHODS : The aim of our study was to evaluate the ability of non-invasive scores in order to define the degree of liver fibrosis, and to assess the effect of host and viral factors on fibrosis in chronic HCV patients. In a retrospective analysis a total of 814 patients with chronic HCV infection were included. Liver fibrosis scores were calculated, and in particular AST/ALT score APRI, Forns index, and FIB-4 score, and all of them compared with histological classification. RESULTS : We found that non-invasive biochemical scores of fibrosis, have a good performance especially to distinguish mild and moderate fibrosis to advanced fibrosis. In particular, we found that FIB-4 score is an useful screening tool to accurately exclude patients with advanced disease. CONCLUSIONS : Non-invasive liver fibrosis scores are efficient tools in the management and follow-up of HCV patients in clinical practice.