Oncolytic Immunotherapy.


Division of Surgical Oncology, Massachusetts General Hospital, 55 Fruit Street, Yawkey 7B, Boston, MA 02114, USA; Replimune, Inc., Woburn, MA, USA. Electronic address: [Email]


Oncolytic viruses are naturally occurring, or genetically engineered viruses that can be administered via intralesional injections or intravenously to induce cell death in tumor cells and activate antitumor immune responses. This review summarizes several oncolytic viruses in preclinical and clinical trials, describes challenges in clinical implementation, and important areas of future investigation.


Cancer,Immunogenic cell death,Immunotherapy,Intratumoral,Oncolytic virus,Treatment,