Oximetry-Guided normoxic resuscitation following canine cardiac arrest reduces cerebellar Purkinje neuronal damage.

Affiliation

Department of Anesthesiology, Center for Shock Trauma and Anesthesiology Research (STAR), United States. Electronic address: [Email]

Abstract

Animal studies indicate that maintaining physiologic O2 levels (normoxia) immediately after restoration of spontaneous circulation (ROSC) from cardiac arrest (CA) results in less hippocampal neuronal death compared to animals ventilated with 100% O2. This study tested the hypothesis that beneficial effects of avoiding hyperoxia following CA are apparent in the cerebellum and therefore not limited to one brain region.

Keywords

Calbindin,Canine,Cardiac arrest,Cerebellum,Hyperoxia,Iba-1,Inflammation,Macrophage,Microglia,Normoxia,Pulse oximetry,Purkinje neuron,Reperfusion injury,Restoration of spontaneous circulation,Ventilation,