PET Evaluation of Microglial Activation in Non-neurodegenerative Brain Diseases.

Affiliation

Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Westgate Road, Newcastle Upon Tyne, UK. [Email]

Abstract

Microglial cell activation is an important component of neuroinflammation, and it is generally well accepted that chronic microglial activation is indicative of accumulating tissue damage in neurodegenerative conditions, particularly in the earlier stages of disease. Until recently, there has been less focus on the role of neuroinflammation in other forms of neurological and neuropsychiatric conditions. Through this review, we hope to demonstrate the important role TSPO PET imaging has played in illuminating the pivotal role of neuroinflammation and microglial activation underpinning these conditions.

Keywords

Microglial activation,Neuroinflammation,Neurological diseases,Neuropsychiatric diseases,PET,TSPO,

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