PTTG overexpression in non-functioning pituitary adenomas: Correlation with invasiveness, female gender and younger age.

Affiliation

PostGraduate Program in Pathology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, CEP: 90050-170 Porto Alegre, RS, Brazil; Neuroendocrinology Center, Santa Casa de Porto Alegre/UFCSPA, Rua Professor Annes Dias, 295, CEP: 90020-090 Porto Alegre, RS, Brazil. Electronic address: [Email]

Abstract

BACKGROUND : Non-functioning pituitary adenomas (NFPA) are prevalent pituitary neoplasms. Because they do not present with hormonal hypersecretion, there is no marker that indicates regrowth or recurrence, as in other adenomas.
OBJECTIVE : Evaluate the immunohistochemical expression of PTTG, CD105 and Ki-67 and their relationships with age, gender, invasiveness, hormonal expression and regrowth or recurrence in the follow-up of NFPA operated and not submitted to radiotherapy.
METHODS : Included 56 patients submitted to transsphenoidal surgery. Clinical data were obtained from medical records. The invasion degree was obtained by Hardy's classification.
RESULTS : Mean age 55 ± 13.6 years, 62.5% men and 68% invasive. Lesion persistence was present in 62.2% and regrowth in 35.7%. The recurrence-free survival rate was 94.5%, 75.4% and 69.1% (1, 2 and 3 years). No patient presented recurrence. The PTTG was positive in 55.3%, with statistically significant relationship with invasiveness, age and female gender, without relation to regrowth. The microvascular density showed statistically significant relationship with male gender, negative correlation with PTTG (r = -0.434, p = 0.001), and no relation with invasiveness and regrowth. The Ki-67 showed statistically significant relationship with age, tendency towards regrowth (p = 0.054) and, with no relation to invasiveness.
CONCLUSIONS : It is suggested that PTTG can be used as a prognostic marker in NFPA.

Keywords

CD105 antigen,Immunohistochemistry,Ki-67 antigen,Microvascular density,Non-functioning pituitary adenomas,PTTG protein,

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