Pharmacologically evoked apnoeas. Receptors and nervous pathways involved.


Department of Respiration Physiology, Mossakowski Medical Research Centre Polish Academy of Sciences, A. Pawińskiego 5, 02-106 Warsaw, Poland. Electronic address: [Email]


This review analyses the knowledge about the incidence of transient apnoeic spells, induced by substances which activate vagal chemically sensitive afferents. It considers the specificity and expression of appropriate receptors, and relevant research on pontomedullary circuits contributing to a cessation of respiration. Insight is gained into an excitatory drive of 5-HT1A serotonin receptors in overcoming opioid-induced respiratory inhibition.


5-HT(1A) receptors,5-HT(3) receptors,Apnoea,TRPV1 receptors,Vagus nerve,μ receptors,