Pioglitazone suppresses macrophage proliferation in apolipoprotein-E deficient mice by activating PPARγ.

Affiliation

Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. Electronic address: [Email]

Abstract

Local macrophage proliferation is linked to enhanced atherosclerosis progression. Our previous study found that troglitazone, a thiazolidinedione (TZD), suppressed oxidized low-density lipoprotein (Ox-LDL)-induced macrophage proliferation. However, its effects and mechanisms are unclear. Therefore, we investigated the effects of pioglitazone, another TZD, on macrophage proliferation.

Keywords

Atherosclerosis,Macrophage,Peroxisome proliferator-activated receptor-γ,Thiazolidinedione,