Polymorphisms in IL36G gene are associated with plaque psoriasis.

Affiliation

Department of Dermatology and Venerology, University of Tartu, 31 Raja St, 50417, Tartu, Estonia. [Email]

Abstract

Plaque psoriasis is a non-contagious skin disease in which characteristic red and flaky lesions result from a dysregulation involving both innate and adaptive immune mechanisms. Several cytokines have been implicated in these processes and lately interleukin (IL)-36 family members have become more recognised among them. Thus far, genetic studies have only investigated IL36RN gene of this family in relation to pustular psoriasis. Since IL36G has previously demonstrated markedly increased levels in plaque psoriasis patients and is linked to IL-23/IL-17 axis critical in psoriasis pathology, it was chosen to be the focus of current report.

Keywords

Cytokines,Genetic association study,IL36G,Plaque psoriasis,SNP,