Population-Based Relative Risks for Lung Cancer Based on Complete Family History of Lung Cancer.

Affiliation

Division of Thoracic Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address: [Email]

Abstract

Published risk estimates for diagnosis of lung cancer based on family history are typically focused on close relatives, rather than a more diverse or complete family history. This study provides estimates of relative risk (RR) for lung cancer based on comprehensive family history data obtained from a statewide cancer registry linked to a high-quality genealogy data resource that is extensive and deep. The risk estimates presented avoid common recall, recruitment, ascertainment biases, and are based on an individual's (proband's) lung cancer family history constellation (pattern of lung cancer affected relatives); numerous constellations are explored.

Keywords

Family history,Genetic epidemiology,Hereditary factors,Lung cancer,