Prevention of delayed hemolytic transfusion reaction.


Établissement Français du Sang, Inserm U955, Team 2, Paris Est University Creteil (UPEC), France. Electronic address: [Email]


Post-transfusion hemolysis is the most frequent immune reaction to transfusion in sickle cell disease. Its frequency is underestimated due to its biological and clinical characteristics. It results principally from the high incidence of alloimmunization in these patients, but no antibodies are detectable in 30% of cases. Prevention is based on the prevention of alloimmunization through the use of matched RBCs for highly immunogenic blood groups, taking into account the patient's transfusion history, particularly in patients undergoing occasional transfusion, which is associated with a higher risk of DHTR development than chronic transfusion. In addition to the use of matched RBCs, the prevention of alloimmunization through immunotherapy should be considered.


Alloimmunisation,Alloimmunization,Drépanocytose,Post-transfusion hemolysis,Prevention,Réaction hémolytique post-transfusionnelle,Sickle cell disease,Transfusion,